Profile Pemenang Juara 1 Best Research 2014

  • Nama : Prof. Dr. Edy Meiyanto, M.Si. Apt
  • TTL : Solo, 2 Mei 1962
  • Jabatan : Profesor 
  • Institusi : Fakultas Farmasi Universitas Gadjah Mada 
  • Alamat : Cancer Chemoprevention Research Center Fakultas Farmasi UGM Sekip Utara Yogyakarta 55281 
  • Email : meiyan e@ugm.ac.id 

Pendidikan

No.

Tingkat

Jurusan

Nama&Tempat
PerguruanTinggi

Tahun Lulus

1

S-1

Ilmu Farmasi

Fak. Farmasi UGM

1986

2

Profesi

Profesi Apoteker

Fak. Farmasi UGM

1987

3

S-2

Ilmu Farmasi

Fak. Farmasi UGM

1995

4

S-3

Molecular oncology

NAIST - Japan

2001

 

Pengalaman Profesional

No.

Tahun

Posisi

Bidang Pekerjaan

Perusahaan/Institusi

1

2004-2014

Ketua

Research Group

Cancer Chemoprevention Research Center,

Fakultas Farmasi UGM

2

2010-2014

Ketua

Organisasi

Indonesian Society for Cancer Chemoprevention

3

2008-2012

Wakil Dekan

Kemahasiswaan, Alumni, Kerja sama, dan Pengembangan

Fakultas Farmasi UGM

4

2005-2008

Wakil Dekan

Kemahasiswaan, Alumni, Riset, dan Kerjasama

Fakultas Farmasi UGM

 

Bidang Ilmu Penelitian

Obat/Sediaan Obat

Judul Penelitian

Curcumin Analogues: New Potential Anticancer Targeted on Cell Cycle and Signal Transduction in Breast Cancer

Tahun Penelitian

2006-2014

Dampak/Aplikasi Hasil Penelitian

Hasil penelitian dapat dimanfaatkan sebagai terapi kanker payudara yang efektif, mudah didapatkan, dan lebih terjangkau dengan target yang spesifik.

Abstrak Penelitian

Cell cycle and signal transduction are the main physiological markers of cancer progression, thus new anticancer development should be addressed to those of the regulation. We develop new pharmacological activities of two curcumin analogues, namely PGV-0 and PGV-1 as anticancer targeted on G2/M phase of the cell cycle and HER2 signaling. We use HER2 transfected breast cancer cells (MCF-7/HER2) as well as MCF-7, MCF-7 resistant doxorubicin (MCF-7/Dox), and T47D. Beside physiological and molecular analysis to some of cancer cells, we did molecular docking approach to explore the specific target receptor of the compound. Physiological examination covering cell cycle assay and apoptosis by using flowcytometry; while molecular mechanisms were examined by using western blot, luciferase assay, and immunofluorescence. The three compounds performed different cell cycle profile. Curcumin caused G2/M arrest with little subG1 arrest; PGV-0 caused S-phase arrest, while PGV-1 caused excessive cell cycle arrest in G2/M and subG1 phase. PGV-1 also inhibited tubulin depolymerization, which is similar with molecular mechanism caused by Taxol. PGV-1 also was the most potent compound to inhibit activation of NF?B and increase the level of pro-apoptotic protein. Curcumin and PGV-0, not PGV-1, possessed target on HER2 localization. From molecular docking simulation, curcumin performed the most stabile interaction with EGFR, HER2, and IKK among others. These results showed that curcumin analogues showed different molecular mechanism and potential to be developed as anticancer agent targeted on cell cycle and signal transduction. 

Nama Peneliti

  1. Prof. Edy Meiyanto, M.Si., Apt.
  2. Dr. Muhammad Da’I, M.Si., Apt.
  3. Endah Puji Septisetiani, M.Sc., Apt.
  4. Aditya Fitriasari, M.Sc., Apt.
  5. Ulfatul Husnaa, M.Biotech.
  6. Yonika Arum Larasati, S.Farm.

Penghargaan yang pernah Didapatkan

  1. Development of Specific Molecular-Targeted Agents to Increase Sensitivity of resistance Breast Cancer Cells to Chemoterapeutic Agent (Hibah Kerja Sama Luar Negeri DIKTI, 2012-2014)
  2. Exploration of anticancer mechanism of curcumin analogues and metabolites of Indonesian herbs (Kerja Sama dengan NAIST, 2008-2010)

Publikasi yang pernah Diterbitkan

  1. Meiyanto E, Putri DD, Susidarti RA, Murwanti R, Sardjiman, Fitriasari A, Husnaa U, Purnomo H, Kawaichi M. Curcumin and its Analogues (PGV-0 and PGV-1) Enhance Sensitivity of Resistant MCF-7 Cells to Doxorubicin through Inhibition of HER2 and NFkB Activation. Asian Pac J Cancer Prev. 2014. 15(1):179-84
  2. Endah Puji Septisetyani, Muthi’ Ikawati, Barinta Widaryanti and Edy Meiyanto, 2008,Apoptosis mediated cytotoxicity of curcumin analogues PGV-0 and PGV-1 in WiDr cell line, Proceeding The International symposium on Molecular targeted Therapy, ISBN:978-979-95107-6-1, Faculty of Pharmacy UGM, pp. 48-56
  3. Widaryanti B., Meiyanto E., Dai M., and Kawaichi M., 2008, PGV-1 is a potent anti mitotic agent, Indon. J. Pharm, 19(3): 145-150
  4. Dai M., Jenie UA, Supardjan AM, Kawaichi M, and Meiyanto E., 2007, T47D cells arrested at G2M and Hyperploidy formation induced by a curcumin analogue, PGV-1,Indon. J. Biotechnol., 12 (2): 1005-1012
  5. Dai M., Supardjan AM., Meiyanto E., and Jenie UA., 2007, Geometrics isomers and cytotoxic effect on T47D cells of curcumin analogues PGV-0 and PGV-1, Majalah Farmasi Indonesia, 18 (1)
  6. Meiyanto, E., Supardjan, Da’i, M, Agustina, D, 2007, Pentagamavunon-0 induces Apoptosis on T47D breast cancer cell line through Caspase-3 activation, Jurnal Kedokteran Yarsi, 15(2): 075-079
  7. Nurulita, NA., and Meiyanto, E., 2006, Efek antikanker PGV-0 terhadap sel kanker payudara T47D yang diinduksi 17-b-estradiol melalui mekanisme apoptosis dan penghambatan angiogenesis, Sains Kesehatan, 19, (1): 109-125